SrasV1, Main, Exploration, bibRecord, 005179

Pulmonary pathology of severe acute respiratory syndrome in Toronto

Identifieur interne : 005179 ( Main/Exploration ); précédent : 005178; suivant : 005180

Pulmonary pathology of severe acute respiratory syndrome in Toronto

Auteurs : David M. Hwang ; Dean W. Chamberlain ; Susan M. Poutanen ; Donald E. Low ; Sylvia L. Asa ; Jagdish Butany

Source :

Modern Pathology [ 0893-3952 ] ; 2004.

RBID : PMC:7100506

Descripteurs français

KwdFr :
- ARN viral (génétique), ARN viral (isolement et purification), Adulte, Adulte d'âge moyen, Antigènes CD (analyse), Antigènes de différenciation des myélomonocytes (analyse), Aspergillose (anatomopathologie), Aspergillose (microbiologie), Aspergillus (croissance et développement), Autopsie, Canada, Cytomegalovirus (croissance et développement), Facteurs de transcription (analyse), Femelle, Herpès (anatomopathologie), Herpès (virologie), Humains, Immunohistochimie, Infections à cytomégalovirus (anatomopathologie), Infections à cytomégalovirus (virologie), Kératines (analyse), Mycoses pulmonaires (anatomopathologie), Mycoses pulmonaires (microbiologie), Mâle, Poumon (), Poumon (anatomopathologie), Poumon (microbiologie), Protéines de la matrice virale (analyse), Protéines nucléaires (analyse), RT-PCR, Simplexvirus (croissance et développement), Sujet âgé, Sujet âgé de 80 ans ou plus, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (croissance et développement), Virus du SRAS (génétique).
MESH :
- analyse : Antigènes CD, Antigènes de différenciation des myélomonocytes, Facteurs de transcription, Kératines, Protéines de la matrice virale, Protéines nucléaires.
- anatomopathologie : Aspergillose, Herpès, Infections à cytomégalovirus, Mycoses pulmonaires, Poumon, Syndrome respiratoire aigu sévère.
- croissance et développement : Aspergillus, Cytomegalovirus, Simplexvirus, Virus du SRAS.
- génétique : ARN viral, Virus du SRAS.
- isolement et purification : ARN viral.
- microbiologie : Aspergillose, Mycoses pulmonaires, Poumon.
- virologie : Herpès, Infections à cytomégalovirus, Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Autopsie, Canada, Femelle, Humains, Immunohistochimie, Mâle, Poumon, RT-PCR, Sujet âgé, Sujet âgé de 80 ans ou plus.

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Antigens, CD (analysis), Antigens, Differentiation, Myelomonocytic (analysis), Aspergillosis (microbiology), Aspergillosis (pathology), Aspergillus (growth & development), Autopsy, Canada, Cytomegalovirus (growth & development), Cytomegalovirus Infections (pathology), Cytomegalovirus Infections (virology), Female, Herpes Simplex (pathology), Herpes Simplex (virology), Humans, Immunohistochemistry, Keratins (analysis), Lung (chemistry), Lung (microbiology), Lung (pathology), Lung Diseases, Fungal (microbiology), Lung Diseases, Fungal (pathology), Male, Middle Aged, Nuclear Proteins (analysis), RNA, Viral (genetics), RNA, Viral (isolation & purification), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (genetics), SARS Virus (growth & development), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology), Simplexvirus (growth & development), Thyroid Nuclear Factor 1, Transcription Factors (analysis), Viral Matrix Proteins (analysis).
MESH :
- chemical , analysis : Antigens, CD, Antigens, Differentiation, Myelomonocytic, Keratins, Nuclear Proteins, Transcription Factors, Viral Matrix Proteins.
- chemistry : Lung.
- chemical , genetics : RNA, Viral, SARS Virus.
- growth & development : Aspergillus, Cytomegalovirus, SARS Virus, Simplexvirus.
- chemical , isolation & purification : RNA, Viral.
- microbiology : Aspergillosis, Lung, Lung Diseases, Fungal.
- pathology : Aspergillosis, Cytomegalovirus Infections, Herpes Simplex, Lung, Lung Diseases, Fungal, Severe Acute Respiratory Syndrome.
- virology : Cytomegalovirus Infections, Herpes Simplex, Severe Acute Respiratory Syndrome.
- Adult, Aged, Aged, 80 and over, Autopsy, Canada, Female, Humans, Immunohistochemistry, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Thyroid Nuclear Factor 1.

Abstract

The severe acute respiratory syndrome (SARS) pandemic in Toronto resulted in a large number of autopsies on its victims. We describe the pulmonary pathology of patients who died in the 2003 Toronto outbreak. Autopsy material from the lungs of 20 patients who died between March and July 2003 were characterized by histology, molecular biology, and immunohistochemistry for cytokeratins, thyroid transcription factor-1, CD68, Epstein–Barr virus, cytomegalovirus, and human herpes simplex viruses. Matched controls were obtained from patients who died of other causes over the same interval. The mean duration of illness was 27 days (range 5–108 days). Post-mortem lung tissues from 19 of 20 patients with probable SARS were positive for SARS-associated coronavirus by RT-PCR. Histologically, all patients showed varying degrees of exudative and proliferative phase acute lung injury, evidenced in conventional and immunohistochemical stains by edema, inflammatory infiltrate, pneumocyte hyperplasia, fibrinous exudates, and organization. Eight of 20 patients showed predominantly a diffuse alveolar damage pattern of acute lung injury, six showed predominantly an acute fibrinous and organizing pneumonia pattern, and the remainder showed an admixture of the two patterns. Squamous metaplasia and scattered multinucleate giant cells were present in most cases. Vascular fibrin thrombi were a common finding and were often associated with pulmonary infarcts. Special stains demonstrated vascular endothelial damage of both small- and mid-sized pulmonary vessels. Two cases were complicated by invasive fungal disease consistent with Aspergillosis, and another by coinfection with cytomegalovirus. Our findings indicate that the lungs of patients who die of SARS are almost always positive for the SARS-associated coronavirus by RT-PCR, and may show features of both diffuse alveolar damage and acute fibrinous and organizing pneumonia patterns of acute injury. Cases of SARS may be complicated by coexistent infections and therapy-related lung injury.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7100506

DOI: 10.1038/modpathol.3800247
PubMed: 15272286
PubMed Central: 7100506

Affiliations:

Le document en format XML

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<author><name sortKey="Poutanen, Susan M" sort="Poutanen, Susan M" uniqKey="Poutanen S" first="Susan M" last="Poutanen">Susan M. Poutanen</name>
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<author><name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name>
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<author><name sortKey="Asa, Sylvia L" sort="Asa, Sylvia L" uniqKey="Asa S" first="Sylvia L" last="Asa">Sylvia L. Asa</name>
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<wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry>
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<wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry>
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<author><name sortKey="Butany, Jagdish" sort="Butany, Jagdish" uniqKey="Butany J" first="Jagdish" last="Butany">Jagdish Butany</name>
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<wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry>
</affiliation>
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</institution-wrap>
Toronto, Ontario Canada</nlm:aff>
<wicri:noCountry code="subfield">Ontario Canada</wicri:noCountry>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
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<term>Antigens, CD (analysis)</term>
<term>Antigens, Differentiation, Myelomonocytic (analysis)</term>
<term>Aspergillosis (microbiology)</term>
<term>Aspergillosis (pathology)</term>
<term>Aspergillus (growth & development)</term>
<term>Autopsy</term>
<term>Canada</term>
<term>Cytomegalovirus (growth & development)</term>
<term>Cytomegalovirus Infections (pathology)</term>
<term>Cytomegalovirus Infections (virology)</term>
<term>Female</term>
<term>Herpes Simplex (pathology)</term>
<term>Herpes Simplex (virology)</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Keratins (analysis)</term>
<term>Lung (chemistry)</term>
<term>Lung (microbiology)</term>
<term>Lung (pathology)</term>
<term>Lung Diseases, Fungal (microbiology)</term>
<term>Lung Diseases, Fungal (pathology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nuclear Proteins (analysis)</term>
<term>RNA, Viral (genetics)</term>
<term>RNA, Viral (isolation & purification)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (growth & development)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Simplexvirus (growth & development)</term>
<term>Thyroid Nuclear Factor 1</term>
<term>Transcription Factors (analysis)</term>
<term>Viral Matrix Proteins (analysis)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ARN viral (génétique)</term>
<term>ARN viral (isolement et purification)</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Antigènes CD (analyse)</term>
<term>Antigènes de différenciation des myélomonocytes (analyse)</term>
<term>Aspergillose (anatomopathologie)</term>
<term>Aspergillose (microbiologie)</term>
<term>Aspergillus (croissance et développement)</term>
<term>Autopsie</term>
<term>Canada</term>
<term>Cytomegalovirus (croissance et développement)</term>
<term>Facteurs de transcription (analyse)</term>
<term>Femelle</term>
<term>Herpès (anatomopathologie)</term>
<term>Herpès (virologie)</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Infections à cytomégalovirus (anatomopathologie)</term>
<term>Infections à cytomégalovirus (virologie)</term>
<term>Kératines (analyse)</term>
<term>Mycoses pulmonaires (anatomopathologie)</term>
<term>Mycoses pulmonaires (microbiologie)</term>
<term>Mâle</term>
<term>Poumon ()</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (microbiologie)</term>
<term>Protéines de la matrice virale (analyse)</term>
<term>Protéines nucléaires (analyse)</term>
<term>RT-PCR</term>
<term>Simplexvirus (croissance et développement)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Virus du SRAS (croissance et développement)</term>
<term>Virus du SRAS (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antigens, CD</term>
<term>Antigens, Differentiation, Myelomonocytic</term>
<term>Keratins</term>
<term>Nuclear Proteins</term>
<term>Transcription Factors</term>
<term>Viral Matrix Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Antigènes CD</term>
<term>Antigènes de différenciation des myélomonocytes</term>
<term>Facteurs de transcription</term>
<term>Kératines</term>
<term>Protéines de la matrice virale</term>
<term>Protéines nucléaires</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Aspergillose</term>
<term>Herpès</term>
<term>Infections à cytomégalovirus</term>
<term>Mycoses pulmonaires</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Lung</term>
</keywords>
<keywords scheme="MESH" qualifier="croissance et développement" xml:lang="fr"><term>Aspergillus</term>
<term>Cytomegalovirus</term>
<term>Simplexvirus</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Viral</term>
<term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Aspergillus</term>
<term>Cytomegalovirus</term>
<term>SARS Virus</term>
<term>Simplexvirus</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN viral</term>
<term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>RNA, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>ARN viral</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Aspergillose</term>
<term>Mycoses pulmonaires</term>
<term>Poumon</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Aspergillosis</term>
<term>Lung</term>
<term>Lung Diseases, Fungal</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aspergillosis</term>
<term>Cytomegalovirus Infections</term>
<term>Herpes Simplex</term>
<term>Lung</term>
<term>Lung Diseases, Fungal</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Herpès</term>
<term>Infections à cytomégalovirus</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Cytomegalovirus Infections</term>
<term>Herpes Simplex</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Autopsy</term>
<term>Canada</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Thyroid Nuclear Factor 1</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Autopsie</term>
<term>Canada</term>
<term>Femelle</term>
<term>Humains</term>
<term>Immunohistochimie</term>
<term>Mâle</term>
<term>Poumon</term>
<term>RT-PCR</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="Par1">The severe acute respiratory syndrome (SARS) pandemic in Toronto resulted in a large number of autopsies on its victims. We describe the pulmonary pathology of patients who died in the 2003 Toronto outbreak. Autopsy material from the lungs of 20 patients who died between March and July 2003 were characterized by histology, molecular biology, and immunohistochemistry for cytokeratins, thyroid transcription factor-1, CD68, Epstein–Barr virus, cytomegalovirus, and human herpes simplex viruses. Matched controls were obtained from patients who died of other causes over the same interval. The mean duration of illness was 27 days (range 5–108 days). Post-mortem lung tissues from 19 of 20 patients with probable SARS were positive for SARS-associated coronavirus by RT-PCR. Histologically, all patients showed varying degrees of exudative and proliferative phase acute lung injury, evidenced in conventional and immunohistochemical stains by edema, inflammatory infiltrate, pneumocyte hyperplasia, fibrinous exudates, and organization. Eight of 20 patients showed predominantly a diffuse alveolar damage pattern of acute lung injury, six showed predominantly an acute fibrinous and organizing pneumonia pattern, and the remainder showed an admixture of the two patterns. Squamous metaplasia and scattered multinucleate giant cells were present in most cases. Vascular fibrin thrombi were a common finding and were often associated with pulmonary infarcts. Special stains demonstrated vascular endothelial damage of both small- and mid-sized pulmonary vessels. Two cases were complicated by invasive fungal disease consistent with Aspergillosis, and another by coinfection with cytomegalovirus. Our findings indicate that the lungs of patients who die of SARS are almost always positive for the SARS-associated coronavirus by RT-PCR, and may show features of both diffuse alveolar damage and acute fibrinous and organizing pneumonia patterns of acute injury. Cases of SARS may be complicated by coexistent infections and therapy-related lung injury.</p>
</div>
</front>
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</author>
<author><name sortKey="Low, De" uniqKey="Low D">DE Low</name>
</author>
<author><name sortKey="Henry, B" uniqKey="Henry B">B Henry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Booth, Cm" uniqKey="Booth C">CM Booth</name>
</author>
<author><name sortKey="Matukas, Lm" uniqKey="Matukas L">LM Matukas</name>
</author>
<author><name sortKey="Tomlinson, Ga" uniqKey="Tomlinson G">GA Tomlinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, P" uniqKey="Tang P">P Tang</name>
</author>
<author><name sortKey="Louie, M" uniqKey="Louie M">M Louie</name>
</author>
<author><name sortKey="Richardson, Se" uniqKey="Richardson S">SE Richardson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name>
</author>
<author><name sortKey="Gunther, S" uniqKey="Gunther S">S Gunther</name>
</author>
<author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name>
</author>
<author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name>
</author>
<author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name>
</author>
<author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name>
</author>
<author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name>
</author>
<author><name sortKey="Schutten, M" uniqKey="Schutten M">M Schutten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
<author><name sortKey="Hui, D" uniqKey="Hui D">D Hui</name>
</author>
<author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tsang, Kw" uniqKey="Tsang K">KW Tsang</name>
</author>
<author><name sortKey="Ho, Pl" uniqKey="Ho P">PL Ho</name>
</author>
<author><name sortKey="Ooi, Gc" uniqKey="Ooi G">GC Ooi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nicholls, Jm" uniqKey="Nicholls J">JM Nicholls</name>
</author>
<author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name>
</author>
<author><name sortKey="Lee, Kc" uniqKey="Lee K">KC Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Shen, H" uniqKey="Shen H">H Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franks, Tj" uniqKey="Franks T">TJ Franks</name>
</author>
<author><name sortKey="Chong, Py" uniqKey="Chong P">PY Chong</name>
</author>
<author><name sortKey="Chui, P" uniqKey="Chui P">P Chui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lang, Z" uniqKey="Lang Z">Z Lang</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chong, Py" uniqKey="Chong P">PY Chong</name>
</author>
<author><name sortKey="Chui, P" uniqKey="Chui P">P Chui</name>
</author>
<author><name sortKey="Ling, Ae" uniqKey="Ling A">AE Ling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tse, Gm" uniqKey="Tse G">GM Tse</name>
</author>
<author><name sortKey="To, Kf" uniqKey="To K">KF To</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mazzulli, T" uniqKey="Mazzulli T">T Mazzulli</name>
</author>
<author><name sortKey="Farcas, Ga" uniqKey="Farcas G">GA Farcas</name>
</author>
<author><name sortKey="Poutanen, Sm" uniqKey="Poutanen S">SM Poutanen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beasley, Mb" uniqKey="Beasley M">MB Beasley</name>
</author>
<author><name sortKey="Franks, Tj" uniqKey="Franks T">TJ Franks</name>
</author>
<author><name sortKey="Galvin, Jr" uniqKey="Galvin J">JR Galvin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Ding, Y" uniqKey="Ding Y">Y Ding</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="To, Kf" uniqKey="To K">KF To</name>
</author>
<author><name sortKey="Tong, Jh" uniqKey="Tong J">JH Tong</name>
</author>
<author><name sortKey="Chan, Pk" uniqKey="Chan P">PK Chan</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Asa, Sylvia L" sort="Asa, Sylvia L" uniqKey="Asa S" first="Sylvia L" last="Asa">Sylvia L. Asa</name>
<name sortKey="Butany, Jagdish" sort="Butany, Jagdish" uniqKey="Butany J" first="Jagdish" last="Butany">Jagdish Butany</name>
<name sortKey="Chamberlain, Dean W" sort="Chamberlain, Dean W" uniqKey="Chamberlain D" first="Dean W" last="Chamberlain">Dean W. Chamberlain</name>
<name sortKey="Hwang, David M" sort="Hwang, David M" uniqKey="Hwang D" first="David M" last="Hwang">David M. Hwang</name>
<name sortKey="Low, Donald E" sort="Low, Donald E" uniqKey="Low D" first="Donald E" last="Low">Donald E. Low</name>
<name sortKey="Poutanen, Susan M" sort="Poutanen, Susan M" uniqKey="Poutanen S" first="Susan M" last="Poutanen">Susan M. Poutanen</name>
</noCountry>
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</affiliations>
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Pulmonary pathology of severe acute respiratory syndrome in Toronto

Pulmonary pathology of severe acute respiratory syndrome in Toronto

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